2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1558
    Bifemelane 90293-01-9 98%
    Bifemelane is a nootropic compound. Bifemelan causes the first peak by stimulating release from intracellular Ca2+ stores and the second by capacitive entry through store–operated Ca2+ channels. Bifemelane will be provided as a pharmacological tool for basic studies on astrocytes.
    Bifemelane
  • HY-B1562
    Bopindolol 62658-63-3 98%
    Bopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a proagent of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research.
    Bopindolol
  • HY-B1585
    Caramiphen 77-22-5
    Parpanil is an anticholinergic agent with NMDA receptor antagonist activity. Parpanil can be used to inhibit diseases related to cholinergic neurotransmission. Parpanil exerts its pharmacological effects by blocking cholinergic effects.
    Caramiphen
  • HY-B1589
    (±)-Carbinoxamine 486-16-8 98%
    (±)-Carbinoxamine is a histamine H1 receptor antagonist.
    (±)-Carbinoxamine
  • HY-B1594
    Carbromal 77-65-6 98%
    Carbromal (Adalin; Adisomnol) is a sedative with centrally depressant effects.
    Carbromal
  • HY-B1656
    Fomocaine 17692-39-6 98%
    Fomocaine (P 652) is an orally active local agent that can suppress or relieve pain. Fomocaine shows antiarrhythmic activity.
    Fomocaine
  • HY-B1657
    Fosphenytoin 93390-81-9 98%
    Fosphenytoin is a phosphate ester proagent developed as an alternative to intravenous phenytoin for acute intervention of seizures. Fosphenytoin has advantages including more convenient and rapid intravenous administration, availability for intramuscular injection, and low potential for adverse local reactions at injection sites.
    Fosphenytoin
  • HY-B1658
    Frovatriptan 158747-02-5 98%
    Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura.
    Frovatriptan
  • HY-B1665
    Isobutamben 94-14-4
    Isobutamben is an amino ester-type local anaesthetic agent.
    Isobutamben
  • HY-B1721
    Parametadione 115-67-3 98%
    Parametadione (Isoethadione) is an antiepileptic agent.
    Parametadione
  • HY-B1733
    Phenyltoloxamine 92-12-6 98%
    Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM).
    Phenyltoloxamine
  • HY-B1738
    Pralidoxime 6735-59-7
    Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning.
    Pralidoxime
  • HY-B1752
    Quinpirole 80373-22-4 98%
    Quinpirole (LY 171555) is a dopamine D2/D3 receptor agonist with activity in reducing hypothalamic norepinephrine concentrations. The effects of Quinpirole are not produced by the selective D1 agonist SKF 38393 or the dextrorotatory isomer of Quinpirole, which lacks D2 agonist activity. By activating D2 receptors, Quinpirole leads to a decrease in dopamine metabolites, a decrease in hypothalamic norepinephrine concentrations, and a possible increase in MHPG sulfate by enhancing norepinephrine release.
    Quinpirole
  • HY-B1789
    Telenzepine 80880-90-6 98%
    Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM).
    Telenzepine
  • HY-B1914
    Tebufenpyrad 119168-77-3 99.08%
    Tebufenpyrad can induce mitochondrial dysfunction and oxidative damage. Tebufenpyrad induces dose-dependent cell death on N27 cells, with an EC50 value of 3.98 μM.
    Tebufenpyrad
  • HY-B2075
    Dimetacrine 4757-55-5 98%
    Dimetacrine is a useful antidepressant effect, and can be used for the research of various types of depression.
    Dimetacrine
  • HY-D1253
    TP-TRFS 2937819-61-7 98%
    TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR).
    TP-TRFS
  • HY-D1259
    NEP 2414276-32-5 98%
    NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λex/λem=430/535 nm). NEP has the potential for parkinsonism.
    NEP
  • HY-D1398
    LtIA-F 98%
    LtIA-F, a novel fluorescent analogue of LtIA, provides a wealth of pharmacological tools to explore the structure–function relationship, distribution, and ligand binding domain of the α3β2 nAChR subtype.
    LtIA-F
  • HY-D1426
    Di-12-ANEPPQ 217176-86-8 98%
    Di-12-ANEPPQ is a fast-responding membrane potential dye. Di-12-ANEPPQ, the lipophilic dye, shows cell-specific loading and Golgi-like staining patterns with minimal background fluorescence in the slices of neocortex and hippocampus.
    Di-12-ANEPPQ
Cat. No. Product Name / Synonyms Application Reactivity